The researchers created a study comparing a conventiona […]
The researchers created a study comparing a conventionally manufactured injection actuator to a 3D printed syringe. They also recently published a paper entitled "Product Quality Using Inhaled Drugs - Device Combinations Using 3D Printing Technology", which explores the impact of syringes on improving patient care options in a progressive study. Using a Form 2 3D printer, the researchers used a gray and transparent photoreactive liquid resin to produce a layer thickness of 25 μm in vertical and horizontal position by stereolithography (SLA) 3D printing.
The researchers explained that in combination with a commercially available MDI drug canister (120 metering drives, 40 mcg dose of beclomethasone dipropionate per actuation of a 50 microliter solution), the performance attributes of the 3D printed inhalation syringe include spray mode, jetting Dose and aerodynamic particle size distribution. The results were further evaluated by confocal and conventional microscopy to understand the effects of 3D printed materials and process parameters on the quality and performance of MDI products. The 3D printed brake showed a spray pattern with an average ellipticity of 1.067. Therefore, the elliptical ratio of the spray pattern is used as a quick screen for initial evaluation of the syringe nozzle print quality.
In this study, the team also conducted in vitro performance tests, specifically particle size distribution and emission dose. A series of experiments have shown that both conventionally manufactured syringes and 3D printed sample actuators show very similar results. Once properly validated, data generated using 3D printed inhalation devices can provide support for scientific review of the Agency's Oral Inhaled Drug Products (OIDP) and ANDA. While syringe-related 3D printing is an important innovation, in the past few years, the technology has been used to create a variety of medical devices, from the use of antimicrobial materials to patient-specific implants, to the creation of new diagnostics. Methods and training models, etc.
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